МОЛЕКУЛЯРНАЯ ХАРАКТЕРИСТИКА МУЛЬТИРЕЗИСТЕНТНЫХ ШТАММОВ M.TUBERCULOSIS, ЦИРКУЛИРУЮЩИХ НА ТЕРРИТОРИИ КАЗАХСТАНА

Айнур Ахметова; Айнур Акильжанова; Асхат Молкенов; Улыкбек Каиров; Венера Бисмилда; Ляйля Чингисова; Улан Кожамкулов

doi:10.34689/w1v1bz07

SEMEY MEDICAL UNIVERSITY

(Nauka i Zdravookhranenie)

Peer-reviewed scientific medical journal

Science & Healthcare

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MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANTM.TUBERCULOSIS STRAINS DISTRIBUTEDIN THE TERRITORY OF KAZAKHSTAN

Authors

Ainur Akhmetova Автор
Ainur Akilzhanova Автор https://orcid.org/0000-0001-6161-8355
Askhat Molkenov Автор https://orcid.org/0000-0003-2339-5204
Ulykbek Kairov Автор https://orcid.org/0000-0001-8511-8064
Venera Bismilda Автор
Lyailya Chingissova Автор
Ulan Kozhamkulov Автор https://orcid.org/0000-0002-9782-7631

DOI:

https://doi.org/10.34689/w1v1bz07

Keywords:

tuberculosis , spoligotyping , multidrug resistance

Abstract

In spite of that the rate of tuberculosis is decreasing every year in Kazakhstan wide distribution of drug-resistant
tuberculosis threatens tuberculosis control. According to various studies, M.tuberculosis W-Beijing genotype is associated
with drug resistance and more severe forms of tuberculosis. Aim of the study: estimation of mutations spectrum in katG,
fabG-inhA, oxyR-ahpC and rpoB responsible for drug resistance of M. tuberculosis to isoniazid and rifampicin, and determination of genetic families of 103 multidrug resistant clinical isolates of M.tuberculosis spread in Kazakhstan by
Sanger method and spoligotyping, respectively. Among 103 multidrug resistant strains in Kazakhstan mutations at 531
codon Ser→Leu of rpoB gene (87,4%) and at 315 codon Ser→Thr of katG gene (97%) responsible for resistance to
rifampicin and izoniazid respectively were prevailed. More than 80% of multidrug resistant M.tuberculosis strains were
referred to Beijing genotype, the most virulent and widely spread genotype in the world. M. tuberculosis Beijing family strains
prevail among multidrug and drug resistant strains in Kazakhstan.

Author Biography

Ainur Akhmetova

MSc, научный сотрудник Лаборатории геномной и персонализированной
медицины, ЧУ «National Laboratory Astana», Назарбаев университет.

References

Ахметова А.Ж., Акильжанова А.Р., Молкенов А.Б., Каиров У.Е., Бисмилда В.Л., Чингисова Л.Т., Кожамкулов У.А.

Молекулярная характеристика мультирезистентных штаммов M.TUBERCULOSIS, циркулирующих на территории

Казахстана // Наука и Здравоохранение. 2019. 5 (Т.21). С. 45-52.

Аkhmetova A.Zh., Akilzhanova A.R., Molkenov A.B., Kairov U.E., Bismilda V.L., Chingissova L.T., Kozhamkulov U.A.

Molecular characterization of multidrug resistant M.TUBERCULOSIS strains distributed in the territory of Kazakhstan //

Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 5, pp. 45-52.

Ахметова А.Ж., Акильжанова А.Р., Молкенов А.Б., Каиров У.Е., Бисмилда В.Л., Чингисова Л.Т., Кожамкулов У.А.

Қазақстан территориясында таралған көптік дәріге төзімді M.TUBERCULOSIS штаммдарының молекулалық

сипаттамасы // Ғылым және Денсаулық сақтау. 2019. 5 (Т.21). Б. 45-52.

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Published

2026-01-28

Issue

Vol. 21 No. 5 (2019): Issue 5

Section

Статьи

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How to Cite

MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANTM.TUBERCULOSIS STRAINS DISTRIBUTEDIN THE TERRITORY OF KAZAKHSTAN. (2026). Рецензируемый медицинский научно-практический журнал «Наука и здравоохранение», 21(5), 45-52. https://doi.org/10.34689/w1v1bz07

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