ГЕНОТИПИРОВАНИЕ ЛЕКАРСТВЕННО-УСТОЙЧИВЫХ КЛИНИЧЕСКИХ ИЗОЛЯТОВ M. TUBERCULOSIS В КАЗАХСТАНЕ

Улан Кожамкулов; Айнур Ахметова; Венера Бисмилда; Ляйля Чингисова; Айнур Акильжанова

doi:10.34689/78q38j27

SEMEY MEDICAL UNIVERSITY

(Nauka i Zdravookhranenie)

Peer-reviewed scientific medical journal

Science & Healthcare

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GENOTYPING OF DRUG-RESISTANT CLINICAL ISOLATESOF M. TUBERCULOSIS IN KAZAKHSTAN

Authors

Ulan Kozhamkulov Автор https://orcid.org/0000-0002-9782-7631
Ainur Akhmetova Автор https://orcid.org/0000-0002-5557-3338
Venera Bismilda Автор
Lyailya Chingissova Автор
Ainur Akilzhanova Автор https://orcid.org/0000-0001-6161-8355

DOI:

https://doi.org/10.34689/78q38j27

Keywords:

tuberculosis , drug resistance , spoligotyping

Abstract

Tuberculosis, especially drug-resistant tuberculosis remains a major health problem in Kazakhstan. The incidence of
multidrug-resistant tuberculosis in the country was increased by 8 times over 12 years from 1,7 to 13,5 per 100,000
population between 2003 and 2015. According to investigations in different countries Beijing M.tuberculosis family strains
were associated with drug-resistance, specifically with multidrug-resistant tuberculosis. Aim of the study is to conduct
genotyping of 192 drug-resistant clinical isolates of M.tuberculosis in Kazakhstan by spoligotyping technique and determine a
correlation between drug resistance and Beijing M.tuberculosis genotype. Spoligotyping results demonstrated that Beijing
genotype is the most widespread genotype among drug-resistant M. tuberculosis clinical isolates in Kazakhstan (74,48%).
Determination of correlation between drug resistance and Beijing M.tuberculosis genotype showed that the genotype was
found in more than 50% cases among polyresistant (70,9%) and multidrug resistant (87,75%) isolates.

Author Biography

Ulan Kozhamkulov

к.м.н, ведущий научный сотрудник Лаборатории геномной и персонализированной
медицины, ЧУ «National Laboratory Astana», Назарбаев университет

References

Кожамкулов У.А., Ахметова А.Ж., Бисмилда В.Л., Чингисова Л.Т., Акильжанова А.Р. Генотипирование

лекарственно-устойчивых клинических изолятов M. Tuberculosis в Казахстане // Наука и Здравоохранение. 2020. 4

(Т.22). С. 71-79. doi 10.34689/SH.2020.22.4.007

Kozhamkulov U., Akhmetova A., Bismilda V., Chingissova L., Akilzhanova A. Genotyping of drug-resistant clinical

isolates of M. Tuberculosis in Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 4, pp. 71-79. doi

10.34689/SH.2020.22.4.007

Кожамкулов У.А., Ахметова А.Ж., Бисмилда В.Л., Чингисова Л.Т., Акильжанова А.Р. Қазақстанда таралған

дәріге-төзімді M. Tuberculosis клиникалық изоляттарын генотиптеу // Ғылым және Денсаулық сақтау. 2020. 4 (Т.22).

Б. 71-79. doi 10.34689/SH.2020.22.4.007

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Published

2026-01-26

Issue

Vol. 22 No. 4 (2020): Issue 4

Section

Статьи

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

GENOTYPING OF DRUG-RESISTANT CLINICAL ISOLATESOF M. TUBERCULOSIS IN KAZAKHSTAN. (2026). Рецензируемый медицинский научно-практический журнал «Наука и здравоохранение», 22(4), 71-79. https://doi.org/10.34689/78q38j27

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