THE ROLE OF CYTOKINE GENE POLYMORPHISMSIN BACTERIAL INFECTIONS, INCLUDING BRUCELLOSIS.LITERATURE REVIEW

Abstract

Relevance. Studies conducted to date have shown the presence of associations of gene polymorphisms of a number of
cytokines with a predisposition or resistance to the development of many infectious diseases.
Aim. This review is devoted to the analysis of literature on the association of cytokine gene polymorphisms in infectious
diseases of bacterial origin, in particular, with brucellosis.
Search strategy. Search of scientific publications in the search engines Pub Med, Google Scholar, Google Academia, in
the electronic scientific library eLibrary.ru, CyberLeninka 10 years deep. Criteria for search information: years of search
included one decade (2008-2018); publications were in Russian, Kazakh and English; full-textured epidemiological and
clinical studies. Exclusion criteria: publications with animal studies, recurring publications, conference proceedings, and
clinical cases.
Results. An analysis of literature showed that bacterial infections such as tuberculosis, erysipelas and brucellosis are
most often associated with polymorphisms of genes of the following cytokines: TNF-α, IL-10, IL-1β, IL-17A, IL-6.The results
of the analysis also showed that the same polymorphisms in different ethnic groups can be associated with both
predisposition and resistance. Polymorphisms of the IL-6, IL-10, and IL-17 genes were more often associated with
brucellosis.
Conclusion. Thus, such studies must be carried out in a certain population of people of the same nationality.