RISK FACTORS FOR SECONDARY HYPERURICEMIAIN ARTERIAL HYPERTENSION. REVIEW.

Abstract

Background. According to large epidemiological studies, a link has been established between hyperuricemia (HU) and a
high risk of cardiovascular diseases, including serious cardiovascular events such as stroke and coronary heart disease.
Asymptomatic or secondary HU, without clinical signs of joint syndrome, can last for years and be a random finding during
examination, most often with the development of complications from the cardiovascular system. Therefore, it is important to
know the risk factors leading to this pathological condition and correct them in a timely manner at the primary level. In this
literature review, the probable causal risk factors for secondary hypertension (HT) are considered, in particular obesity,
dyslipidemia, long-term administration of low doses of acetylsalicylic acid and loop diuretics.
Aim: Systematic analysis of international and domestic experience of studying the risk factors of HU in HT.
Search strategy: A systematic search was carried out in the electronic databases PubMed, Cochrane library, e-library,
Cyberleninka we also looked at the additional information resource Google Scholar. The inclusion criteria were: reports on
randomized and cohort studies conducted on large populations, meta-analyses and systematic reviews, original full-text
articles in English and Russian that are publicly available and contain statistically confirmed conclusions. Exclusion criteria:
summary reports, newspaper articles and personal messages. The search depth was 10 years (2012-2022). Relevant search returned 4100 articles; after initial analysis, 52 articles were selected for final analysis in accordance with the
inclusion criteria.
Results: According to the results of our literature review, most studies indicate the influence of risk factors such as
obesity, dyslipidemia, long-term use of low doses of acetylsalicylic acid and loop diuretics on the development of
asymptomatic HU in patients with HT.