PROGNOSTIC VALUE OF THE RATIO OF NEUTROPHILS TOLYMPHOCYTES IN ELDERLY PATIENTS WITH ACUTE CORONARYSYNDROME WITHOUT ST ELEVATION

Abstract

Introduction. We investigated the role of the ratio of neutrophils to lymphocytes (NLR) in predicting the severity of
coronary heart disease and left ventricular systolic dysfunction of any degree in the group of elderly patients admitted to the
emergency department with acute coronary syndrome (ACS) without raising the ST segment.

Objective: to assess the predictive role of NLR in relation to the severity of ACS without ST elevation in case of single or
multiple damage of coronary vessels and LV dysfunction in elderly patients.
Methods: we included 106 patients aged ≥60 years with ACS without ST segment elevation who underwent coronary
angiography from January to June 2019. The main study group included 56 patients with severe [> 50%] lesions of one or
more epicardial arteries or branches; the comparison group included 50 patients with coronary artery disease in the absence
of serious coronary artery lesions. A comparison of key clinical parameters in the study groups was carried out, while the
NLR indicator predicted the severity of coronary heart disease and left ventricular systolic dysfunction of any degree. Study
design is transverse. Statistical processing: IBM SPSS Statistics 20, with the determination of the normality of the distribution
of the studied characteristics and the assessment of descriptive statistics of numerical variables. Qualitative variables are
presented as absolute numbers and their percentages.
Results. An analysis of the results of laboratory and instrumental examination of patients with ACS without ST elevation,
included in the study groups, indicates that in the main group with more pronounced ischemic damage to myocardial tissues,
which was confirmed by echocardiography, a study of the level of troponin, the NLR rate was also significantly higher. than in
the comparison group. This indicates a more pronounced inflammation in the heart muscle of the individuals of the main
group.
Conclusion: NLR is a simple, fast, and low-cost parameter that can predict the severity of IHD and left ventricular
systolic dysfunction in elderly patients with ACS without ST segment elevation.