NEED OF IMPROVING THE DIAGNOSTICS OF VIRAL HEPATITIS CIN PATIENTS WITH CHRONIC KIDNEY DISEASE,RECEIVING HEMODIALYSIS

Abstract

This article presents a retrospective analysis of laboratory parameters in patients with end-stage chronic renal failure
receiving lifelong hemodialysis and having a positive test for viral hepatitis C. The indicators of the complete blood count (red
blood cell count, leukocyte count, platelet count, hemoglobin concentration, hematocrit and ESR) were analyzed,
biochemical studies for glucose, total protein, albumin, renal functional tests (glomerular filtration rate - GFR, creatine and
urea), liver function tests (ALT and AST), iron examination (concentration of serum iron and ferritin), C-reactive protein. For
the diagnosis of viral hepatitis C, only the test for the determination of antibodies against viral hepatitis antiHCV (Hepatitis C
virus) was used. A statistical analysis of the obtained data was carried out - the number and percentage, the arithmetic
average, the level of significance P at ≤ 0.05. Assessment of the terminal stage of chronic renal failure in terms of sexual
dimorphism in a comprehensive study of the diagnosis of hepatitis C in patients receiving hemodialysis was made for the first
time. Fluctuations in individual diagnostic and prognostic indicators of laboratory tests, suggesting the involvement of sex
factors in the combined development of viral hepatitis C and chronic renal failure were identified with an unfavorable prognosis. An important conclusion was made that, in order to improve diagnosis, it is necessary to follow the algorithm for
early diagnosis of viral hepatitis C in patients with chronic kidney disease, who are shown to undergo dialysis, according to
the guidelines of KDIGO (Kidney Disease: Improving Global Outcomes, 2018). First of all, it is necessary to include a test for
determining the nucleic acids of the causative agent of viral hepatitis C - the RNA test.