COMBINATIONS OF CONGENITAL HEART DISEASESAND A CONNECTIVE TISSUE DYSPLASIAAMONG CHILDREN OF SEMEY

Abstract

Introduction. There is evidence on common mechanisms of congenital heart diseases (CHD) and
connective tissue dysplasia (CTD), which increases odds for their comorbidities. The latter may be
associated with poorer prognosis for CHD. However, the associations between CHD and CTD in
Kazakhstan have been poorly studied so far.
Aim – to assess the frequency of CTD signs in children with CHD living in Semey, Kazakhstan.
Materials and methods. We examined 168 children aged 1 to14 years, including 84 – with CHD
and 80 children with no signs of CHD.
Associations between CHD and CTD have been studied by Fisher’s exact tests and Pearson’s chisquared tests where appropriate.
Results: Children with CHD and with CTD had comparable frequency of phenotypical signs of the
last. Significant excess of the frequenciest indexes over control group on the majority of signs was
observed. Instrumental researches of heart showed very high frequency of signs of CTD at children
about CHD. It is revealed that undifferentiated CTD is almost inevitable accompanying syndrome at
children with CHD, being observed in 88,1% of cases.