GEOGRAPHICAL DISTRIBUTION OF HBV GENOTYPESAND ASSOCIATION WITH CLINICAL MANIFESTATIONSOF CHRONIC VIRAL HEPATITIS B: REVIEW

Abstract

Relevance. Chronic viral hepatitis B is a global public health problem due to high rates of infection (over 250 million
people) and mortality (about 2 million people).The progression and clinical outcomes of the disease are influenced by many
factors, starting still the biological properties of virus to genetic factors.
Aim. Analysis of literature devoted to the study of the prevalence of genotypes and their impact on the clinical course of
chronic viral hepatitis B.
Search strategy. Search of scientific publications in the search engines Pub Med, Google Scholar, Google Academia, in
the electronic scientific library eLibrary.ru, CyberLeninka. Inclusion criteria: search depth was 15 years (2004-2019);
publications were in Russian, Kazakh and English; full-textured epidemiological and clinical studies.Exclusion criteria:
publications with animal studies, studies related to the study of hepatitis C virus genotypes, with a response to antiviral
therapy, recurring publications, conference proceedings, and clinical cases.
Results.Genotype D is most common and ubiquitous. Genotypes A, B, C have a characteristic geographical distribution
in Europe, the countries of the African contingent (genotype A) and Asia, in particular in China (genotype B) and Korea
(genotype C). Genotype B is more often associated with a favorable prognosis, while an unfavorable course of the disease is
associated with the C genotype.
Conclusion.Thus, genotypes have a characteristic geographical distribution and affect the clinical course and outcomes
of chronic viral hepatitis B.