INFLUENCE OF AGING PROCESSESON REPRODUCTIVE FUNCTION IN MEN

Abstract

Relevance. Aging is a combination of irreversible processes over time observed in all eukaryotic organisms at the level
of cells, tissues, organs and systems. It is known that the reproductive capacity of both men and women decreases with age.
Today, in developed countries, there is a tendency for couples to postpone the birth of a child due to economic reasons,
career planning. This phenomenon has significantly increased the relevance of research to study the effects of aging on the
reproductive system.
Aim. To study the influence of aging processes on reproductive function in men.
Materials and methods. For the search and selection of articles, the PRISMA principle (Preferred Reporting Method for
Systematic Reviews and Meta-analyzes) was used. In this review, the databases MedLine, Cochrane, PubMEd were used.
The search depth was 10 years. All sources have been studied without language limitation. The literature review was carried
out in electronic and manual modes. For the review, articles were selected corresponding to the keywords - Sexual
dysfunction, male reproductive dysfunction, aging.
A total of 563 articles were found, and the search included systematic reviews, meta-analyzes, and randomized clinical
trials. To remove duplicates and select articles, the resource "https://rayyan.ai/" was used. After the selection of articles, 126
sources were selected, which were included in the final synthesis.
Results and discussion. Multidimensional genetic and environmental factors of the environment accelerate aging not
only in somatic cells, but also in the cells of the male sex glands. Thus, aging significantly affects reproductive potential,
including a high risk of chromosomal abnormalities, intrauterine growth retardation and other probable disorders.
However, existing data show that obesity, physical inactivity and concomitant diseases are more detrimental to the male
reproductive system than chronological aging.
Output. The effect of the aging process on the male reproductive system is a rather complex and multifaceted process,
since it is caused not only by normal physiological processes, but also by behavioral and environmental factors. Further
research is needed to study gonadal aging and its effects on the male reproductive system.