EVALUATION OF THE EFFICACY 5-FLUOROURACIL ON ERECTILE FUNCTION IN PATIENTS UNDER SURGICAL TREATMENT OF BENIGN PROSTATE HYPERPLASIA
DOI:
https://doi.org/10.34689/m4dm4j80Keywords:
benign prostatic hyperplasia , surgery , 5-fluorouracil , erectile functionAbstract
Introduction. The prevalence of erectile dysfunction in benign prostatic hyperplasia (BPH) is 5.2-40%. Urethral strictures
as a complication of transurethral resection of the prostate is a risk factor for the development of postoperative erectile
dysfunction.
The purpose of the study is to evaluate the effectiveness of the prophylactic use of 5-fluorouracil in relation to erectile
dysfunction in patients undergoing surgery for BPH.
Materials and methods. The study included 246 patients who underwent surgery, with an average age of 70.0±8.0
years. The main group included 124 patients who, in addition to the standard postoperative treatment in the hospital,
received prophylactic intervention after surgery in the form of washing with a solution of 5-fluorouracil using a modified threeway catheter. The control group consisted of 122 combined patients who underwent surgery for BPH and received standard
postoperative treatment. To assess erectile dysfunction, the IIEF-5 questionnaire was used 3 and 6 months after surgery. All
statistical analysis procedures were performed using the SPSS 20 program. For qualitative data, the significance of
differences in groups was determined by calculating the Chi-square (χ2) test. For quantitative data, the result was expressed
as the median and 25-75 percentiles. Calculations of the significance of differences were made using the Mann-Whitney test.
Results. A statistically significant improvement in the erectile function of patients in both the main and control groups
was established after surgery for 6 months (χ2 = 115.356; p < 0.001; χ2 = 115.034; p < 0.001, respectively). At the same
time, in the main study group, the indicators had statistically significant differences with the control group. A twofold decrease
in subjective symptoms of erectile dysfunction was shown in all patients, however, in the main study group, changes in these
indicators were statistically significantly more pronounced (p=0.014 after 3 months; p=0.007 after six months).
Conclusion. The high efficiency of the prophylactic use of 5-fluorouracil by irrigation of the bladder and urethra in
relation to the erectile function of patients who underwent surgery for benign prostatic hyperplasia was established.
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Ғылым және Денсаулық сақтау. 2023. 2 (Т.25). Б. 105-110. doi 10.34689/SH.2023.25.2.015
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Copyright (c) 2026 Ербол Кайрамбаев, Толкын Булегенов, Куат Акимжанов, Муратхан Кудербаев, Александр Неймарк, Ербол Смаил, Оксана Юрковская, Жанар Жуманбаева, Наталья Глушкова (Автор)
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