Immunological changes in children with multisystem inflammatory syndrome associated with SARS-CoV-2
DOI:
https://doi.org/10.34689/ymtj0346Keywords:
multisystem inflammatory syndrome , MIS-C , children , immunophenotypingAbstract
Introduction. SARS-CoV-2-associated multisystem inflammatory syndrome (MIS-C) is characterized by signs and
symptoms reflecting intense immune activation with increased production of cytokines.
Аim. The aim of our study was to study changes in the immune response in children with MVS associated with SARSCoV-2.
Methods. The study included 35 children with MIS-C associated with SARS-CoV-2, the control group consisted of 15
healthy children who had COVID-19 and did not develop MIS-C. The state of the immune response in all patients was
assessed by the method of immunophenotyping of peripheral blood.
Results. Children with MIS-C associated with SARS-CoV-2 had CD3+ T-cell lymphopenia, a decrease in NK cells, a
decrease in the expression of the apoptosis marker CD95, and an increase in the expression of the activation marker CD25.
The change in the humoral immune response was manifested as an increase in the relative number of B-lymphocytes and
an increase in the expression of the B-cell activation marker CD3-HLA-DR+.
Conclusions. Children with MIS-C associated with SARS-CoV-2 have profound immune dysregulation, as evidenced by
our data.
References
Джаксыбаева И.С., Боранбаева Р.З., Булегенова М.Г., Толганбаева А.А., Уразалиева Н.Т., Кустова Е.А., Герайн В.И. Иммунологические изменения у детей с мультисистемным воспалительным синдромом, ассоциированным с SARS-CoV-2 // Наука и Здравоохранение. 2023. №5 (Т.25). С. 27–33. doi: 10.34689/SH.2023.25.5.003
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Copyright (c) 2025 Индира Джаксыбаева, Риза Боранбаева, Минира Булегенова, Айжан Толганбаева, Наталья Уразалиева, Елена Кустова, Валентин Герайн (Автор)
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