IMMUNOHISTOCHEMISTRY IN DIAGNOSTICSOF COLORECTAL CANCER AND THE ROLEOF PROLIFERATION MARKER Ki-67
DOI:
https://doi.org/10.34689/c5fsj253Keywords:
Ki-67 , colorectal cancer , immunohistochemistryAbstract
Introduction: the paper presents literature review devoted to the significance of biomarkers in
colorectal cancer. Based on the analysis of data presented in evidence-based medicine databases,
there is a lot of scientific information enabling appropriate solution of treatment modality.
Aim: to carry the systematic search of research papers dedicated to immunohistochemistry in
colorectal cancer and to the significance of proliferation marker Ki67.
Materials and methods. To achieve the above described goal, we conducted a systematic literature
search in evidence-based medicine electronic databases. The overall number of research papers
identified was equal to 4342, of which 55 were included in the present review.
Results: the role of COX2, HER2, SMAD4, ALDH1 and Ki-67 in immunohistochemistry of colorectal
cancer is studied to the various extent.
Conclusions: Ki67 expression indices in colorectal cancer still require further exploration, while
available literature sources report controversial findings. It might prove to be useful to carry additional
scientific research devoted to the establishment of correlation between Ki67 proliferation labeling,
clinical and morphological characteristics of malignant tumor, and its prognostic meaning in colorectal
cancer.
References
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Copyright (c) 2026 Куанткан Жабагин, Александра Селиверстова, Коркем Салыкбаева, Мухтаргазы Тулеутаев, Нурлыбек Керемханұлы, Нургуль Жумыкбаева, Зухра Манамбаева, Маржан Даулетьярова, Юлия Семенова, Жанар Елемесова (Автор)
This work is licensed under a Creative Commons Attribution 4.0 International License.