TO THE QUESTION OF MICROBIOLOGICAL DIAGNOSISOF TUBERCULOSIS AND DRUG RESISTANCE.LITERATURE REVIEW.

Abstract

Introduction: The main evidential base of diagnosis of tuberculosis and drug resistance is
microbiological diagnostics. In the conditions of the growing threat of tuberculosis with multiple/wide
drug resistance one of key aspects of anti-tuberculosis work is the right choice of fast and reliable
diagnostic methods.
Research aim: the analysis of literature on current state of microbiological diagnosis of tuberculosis,
including with drug resistance in Kazakhstan and some foreign countries
Research strategy: it was carried out the search of scientific publications in databases of evidential
medicine (PubMed, Cochrane Library, ResearchGate) and in the electronic scientific libraries
(CyberLeninka). The depth of search is 10 years (2007-2017). The inclusion criteria were: reports on
randomized and cohort studies conducted on large populations; Meta-analyzes and systematic reviews.
The summary of reports, newspaper publications and personal messages became criteria of an
exception. 149 publications on this subject have been found, 55 of them answered to the purposes of
our research.
Results: In recent years in diagnosis of tuberculosis important breaks have been made. The modern
methods which are available today at laboratories allow to confirm a tuberculosis etiology of a disease
with high probability and to define drug resistance of the microorganism. At the same time, nowadays
there is no diagnostic test that meets all requirements of a "fast", "inexpensive" and "simple".
Conclusions: Further introduction of molecular-genetic methods and a research of the new
technologies market for diagnosis of tuberculosis and drug resistance is necessary, relying on quality,
availability and economic efficiency of expenses.