ASSESSMENT OF BIOCHEMICAL INDICATORS CHARACTERIZINGTHE HEALTH STATUS OF THE POPULATION OF THE EAST KAZAKHSTANREGION EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
DOI:
https://doi.org/10.34689/0c2agg84Keywords:
radiation exposure , nonspecific resistance , biochemical indicatorsAbstract
Introduction: In 2017, the scientific program "Development of scientific and methodological foundations for minimizing
environmental burden, medical provision, social protection and health improvement of the population of ecologically
unfavorable territories of the Republic of Kazakhstan" was started in the SMU. In the framework of the program we studied
the state of health and nonspecific resistance in the population of the East Kazakhstan region exposed to radiation.
Aim: assessment of biochemical indicators characterizing the health status of the studied population
Methods: The sample size in the Abay region was 222 people, in the Borodulikha district it was 233 people, in the
Kurchumsky district it was 245 people. Biochemical indicators (calcium, potassium, sodium, magnesium, glycosylated
hemoglobin, total protein, ALT, AST, thyroid hormones, antibodies to TPO, ACTH, cortisol, insulin) were studied. Inclusion
criteria: age 18-50 years, legally confirmed residence in the territory of the influence of the Test Site. Exclusion criteria:
organic lesion of the central nervous system, somatic diseases in the stage of decompensation. Control - residents of the
Kurchum district. The design is cross-sectional study. Statistical processing: IBM SPSS Statistics 20, with the definition of the
normality of the distribution of the studied characteristics and the evaluation of descriptive statistics of numerical variables.
Qualitative variables are represented in the form of absolute figures and their percentages. Evaluation of differences in
groups is determined by calculating the χ2 criterion.
Results. High levels of thyroid-stimulating hormone were found in the residents of Borodulikha district (13.5%), in Abai
district it was defined in 3.9% of residents. The excess of antibody titre to TPO was recorded in both study groups (80.09 in
Abai and 43.77 in Borodulikha districts). Signs of violations of nonspecific resistance manifested in the changes of the blood
microelements (decrease of magnesium, calcium and potassium), increased cortisol.
Conclusion: Biochemical indicators of violations of nonspecific resistance in the persons exposed to radiation have
been established.
References
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Пивина Л.М., Семенова Ю.М., Жунусов Е.Т., Булегенов Т.А., Манатова А.М., Белихина Т.И., Абишева А.С.,
Эфендиев У.М., Жунусова T. Ядролық қару сынақтары салдарынан радиациялық әсерге шалдыққан Шығыс
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Copyright (c) 2026 Людмила Пивина, Юлия Семенова, Ерсин Жунусов, Толкын Булегенов, Альмира Манатова, Татьяна Белихина, Айгерим Абишева, Умуд Эфендиев, Тамара Жунусова (Автор)
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