ANTIBIOTIC RESISTANCE OF SHIGELLAAT THE PRESENT STAGE

Abstract

Introduction. One of the major problems of practical public health at the present stage is the growth of Shigella's high
antibiotic resistance to those antibacterial drugs that are widely used today in their treatment.
Objective: to study the sensitivity of the Shigella spp. strains isolated from the intestines of patients with acute dysentery
to antimicrobials widely used in clinical practice.
Materials and methods.
A retrospective analysis of 236 medical records of patients with a diagnosis of acute dysentery treated on the basis of the
Astana City Infectious Diseases Hospital for the period 2014-2016 was carried out. The sensitivity of Shigella to antibacterial
drugs was determined in accordance with the guidelines of the Clinical Laboratory Standards Institute (CLSI, 2010) [9]. The degree of intestinal dysbiosis was determined in accordance with the classification of NM Gracheva and others [1, 3].
Statistic analysis of getting information was carried with SPSS program 12.0.2 for Windows.
Results. At the present stage, Sh.flexneri 2а, 2в, 1в, Shigella Sonnei 2е and 2d dominate in the etiological structure of
shigellosis. Doxycycline, trimethoprim, ampicillin, tetracyclines, gentamicin and chloramphenicol cannot be used as starting
therapy for shigellosis because of the fairly high level of resistance to them for shigella that has developed in recent years. In
addition, currently there is a tendency to develop resistance of shigella to fluoroquinolone drugs (ciprofloxacin) and
cephalosporins (cefotaxime, ceftriaxone), which are widely used in the treatment of this disease. In patients with shigellosis,
subcompensated and decompensated disorders in the intestinal microflora are observed, which are aggravated under the
influence of antibacterial drugs.
Conclusion: The development of a tendency to develop resistance of shigellosis pathogens to ciprofloxacin and
cephalosporins (ceftriaxone, cefotaxime) at the present stage requires the supervision of the resistance of shigella to these
antibiotics, which will serve as a basis for taking timely measures for antimicrobial therapy, rational choice of antimicrobial
therapy.