СO-INFECTION (TUBERCULOSIS/HIVINFECTION)AND PREGNANCY. A CLINICAL CASE.

Abstract

In the structure of the incidence of tuberculosis, the problem of pregnancy in women with tuberculosis becomes
particularly acute. This is due to hormonal changes during pregnancy, and the presence of HIV infection worsens the course
and outcome of both tuberculosis and pregnancy. The problem of tuberculosis/HIV co-infection in pregnant women remains
not fully understood.
Tuberculosis (TB) is one of the most common opportunistic infections in HIV-infected patients, especially in regions with
its high prevalence. Pregnant women with co-infection have the worst prognosis, while the main factors affecting the
outcome and prognosis of pregnancy are the severity and prevalence of TB, the presence of its extrapulmonary localizations,
poor adherence to treatment, as well as the duration of pregnancy when TB is detected. These factors also affect the
frequency of obstetric complications such as miscarriages, premature birth, and low newborn body weight. Late diagnosis of
TB is an independent factor that increases the frequency of obstetric pathology by almost 4 times, and the risk of premature
birth by 9 times.
We present a clinical case of a pregnant woman with coinfection (TB/HIV). In the Republic of Kazakhstan, this clinical
case is an isolated one. With this clinical case, we show the diagnosis, course and outcome of tuberculosis treatment in a
pregnant woman with coinfection, as well as the effectiveness of the individual treatment regimen (ITR).